The idea of circumventing the rules of inheritance in order to quickly spread and maintain desired traits through an entire population or species, has long existed. With new genetic engineering techniques for genome editing, such as CRISPR-Cas9, it may soon be possible to turn this idea into reality. It has been claimed that gene drive technology may be used to combat infectious diseases such as malaria, dengue or zika, as well as to reduce the threat posed by agricultural pests and ecologically harmful invasive species. However, a crucial difference with conventional gene technology is that gene drives intentionally target wild populations in order to permanently alter them. Gene drives are a technology that raises fundamental ecological, social, ethical and legal questions.
A working group of international scientists and philosophers has extensively considered these questions. The outcome of this process will be presented for discussion at the Gene Drive Symposium.